Product Data Sheet
Agomelatine-d4
Catalog No. A29979
Agomelatine-d4 is a deuterium-labeled analog of Agomelatine, which serves as a selective agonist for the melatonin receptors MT1 and MT2. It exhibits high affinity with Ki values of 0.1 nM, 0.06 nM, 0.12 nM, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor, with pKi values of 6.4 and 6.2 at porcine and human cloned 5-HT2C receptors. This stable isotope-labeled reagent is valuable for studies involving melatonin receptor signaling and serotonergic pharmacology.
Chemical Information
| Catalog Num | A29979 |
|---|---|
| M. Wt | 247.33 |
| Formula | C15H13D4NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1079389-44-8 |
| Synonyms | S-20098-d4 |
| SMILES | CC(NC([2H])([2H])C([2H])([2H])C1=CC=CC2=C1C=C(OC)C=C2)=O |
Biological Activity
| Description | Agomelatine-d4 is a deuterium-labeled analog of Agomelatine, which serves as a selective agonist for the melatonin receptors MT1 and MT2. It exhibits high affinity with Ki values of 0.1 nM, 0.06 nM, 0.12 nM, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor, with pKi values of 6.4 and 6.2 at porcine and human cloned 5-HT2C receptors. This stable isotope-labeled reagent is valuable for studies involving melatonin receptor signaling and serotonergic pharmacology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
