Product Data Sheet
Copanlisib dihydrochloride
Catalog No. A30054
Copanlisib dihydrochloride is a potent, selective pan-class I PI3K inhibitor that acts through ATP-competitive mechanisms. It exhibits remarkable inhibitory activity with IC50 values of 0.5 nM, 0.7 nM, 3.7 nM, and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ, and PI3Kγ, respectively, demonstrating over 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. This compound has been shown to possess significant antitumor activity, making it a valuable reagent for cancer research and therapeutic development focusing on the PI3K pathway.
Chemical Information
| Catalog Num | A30054 |
|---|---|
| M. Wt | 553.44 |
| Formula | C23H30Cl2N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1402152-13-9 |
| Synonyms | BAY 80-6946 dihydrochloride |
| SMILES | O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25.[H]Cl.[H]Cl |
Biological Activity
| Description | Copanlisib dihydrochloride is a potent, selective pan-class I PI3K inhibitor that acts through ATP-competitive mechanisms. It exhibits remarkable inhibitory activity with IC50 values of 0.5 nM, 0.7 nM, 3.7 nM, and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ, and PI3Kγ, respectively, demonstrating over 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. This compound has been shown to possess significant antitumor activity, making it a valuable reagent for cancer research and therapeutic development focusing on the PI3K pathway. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
