Product Data Sheet
Selumetinib sulfate
Catalog No. A30186
Selumetinib sulfate is a selective, non-ATP-competitive inhibitor of MEK1/2, exhibiting an IC50 of 14 nM against MEK1. By inhibiting the phosphorylation of ERK1/2, Selumetinib sulfate induces apoptosis in cancer cells. Additionally, its ability to penetrate the blood-brain barrier enhances its potential for therapeutic applications in brain tumors and other central nervous system malignancies.
Chemical Information
| Catalog Num | A30186 |
|---|---|
| M. Wt | 555.76 |
| Formula | C17H17BrClFN4O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 943332-08-9 |
| Synonyms | AZD6244 sulfate; ARRY-142886 sulfate |
| SMILES | OCCONC(C(C=C1C(N=CN1C)=C2F)=C2NC3=C(C=C(Br)C=C3)Cl)=O.O=S(O)(O)=O |
Biological Activity
| Description | Selumetinib sulfate is a selective, non-ATP-competitive inhibitor of MEK1/2, exhibiting an IC50 of 14 nM against MEK1. By inhibiting the phosphorylation of ERK1/2, Selumetinib sulfate induces apoptosis in cancer cells. Additionally, its ability to penetrate the blood-brain barrier enhances its potential for therapeutic applications in brain tumors and other central nervous system malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
