Product Data Sheet
Fludrocortisone
Catalog No. A30193
Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. It exhibits significant anti-inflammatory properties by suppressing pro-inflammatory cytokine expression, including CCL2, IL-6, and IL-8 levels, while enhancing renal sodium and water transport, which contributes to increased plasma volume and blood pressure. Additionally, fludrocortisone induces key signaling pathways such as PI3K/Akt, mTOR, and ERK1/2, and is utilized in research applications related to congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.
Chemical Information
| Catalog Num | A30193 |
|---|---|
| M. Wt | 380.45 |
| Formula | C21H29FO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 127-31-1 |
| Synonyms | 9α-Fludrocortisone; 9α-Fluorcortisol |
| SMILES | C[C@@]12[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O |
Biological Activity
| Description | Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. It exhibits significant anti-inflammatory properties by suppressing pro-inflammatory cytokine expression, including CCL2, IL-6, and IL-8 levels, while enhancing renal sodium and water transport, which contributes to increased plasma volume and blood pressure. Additionally, fludrocortisone induces key signaling pathways such as PI3K/Akt, mTOR, and ERK1/2, and is utilized in research applications related to congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
