Product Data Sheet
Ponicidin
Catalog No. A30308
Ponicidin is a selective RIPK1 binder with an affinity of 135 nM for mouse RIPK1, functioning primarily as an apoptosis inducer and cell growth inhibitor. This compound modulates the JAK2/STAT3 signaling pathway to promote apoptosis, activates the PI3K/Akt pathway, and enhances SIRT1 expression. Additionally, Ponicidin exerts neuroprotective effects by alleviating oxidative stress, inhibiting inflammatory responses, and blocking necroptosis, while also increasing ROS production for antiproliferative and antiviral activity. It has significant implications for research in hepatocellular carcinoma, Alzheimer's disease, and gastric cancer.
Chemical Information
| Catalog Num | A30308 |
|---|---|
| M. Wt | 362.42 |
| Formula | C20H26O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 52617-37-5 |
| Synonyms | Rubescensine B |
| SMILES | O[C@]12[C@]3(C4=O)[C@]5([H])C6([C@](O[C@@]3([H])[C@](CC5)([H])C4=C)([H])O2)[C@](C(C)(CC[C@@H]6O)C)([H])[C@@H]1O |
Biological Activity
| Description | Ponicidin is a selective RIPK1 binder with an affinity of 135 nM for mouse RIPK1, functioning primarily as an apoptosis inducer and cell growth inhibitor. This compound modulates the JAK2/STAT3 signaling pathway to promote apoptosis, activates the PI3K/Akt pathway, and enhances SIRT1 expression. Additionally, Ponicidin exerts neuroprotective effects by alleviating oxidative stress, inhibiting inflammatory responses, and blocking necroptosis, while also increasing ROS production for antiproliferative and antiviral activity. It has significant implications for research in hepatocellular carcinoma, Alzheimer's disease, and gastric cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
