Product Data Sheet
Capmatinib dihydrochloride hydrate
Catalog No. A30361
Capmatinib dihydrochloride hydrate is a potent, orally bioavailable inhibitor of c-Met kinase, exhibiting an IC50 value of 0.13 nM. This selective and ATP-competitive inhibitor disrupts the phosphorylation of c-MET and its downstream signaling pathways, including ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate demonstrates substantial antitumor activity by effectively inhibiting c-MET-dependent tumor cell proliferation, migration, and promoting apoptosis. Primarily metabolized by CYP3A4 and aldehyde oxidase, this compound is instrumental in cancer research focused on targeting c-Met-associated pathways.
Chemical Information
| Catalog Num | A30361 |
|---|---|
| M. Wt | 503.36 |
| Formula | C23H21Cl2FN6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1865733-40-9 |
| Synonyms | INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate |
| SMILES | O=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F.O.Cl.Cl |
Biological Activity
| Description | Capmatinib dihydrochloride hydrate is a potent, orally bioavailable inhibitor of c-Met kinase, exhibiting an IC50 value of 0.13 nM. This selective and ATP-competitive inhibitor disrupts the phosphorylation of c-MET and its downstream signaling pathways, including ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate demonstrates substantial antitumor activity by effectively inhibiting c-MET-dependent tumor cell proliferation, migration, and promoting apoptosis. Primarily metabolized by CYP3A4 and aldehyde oxidase, this compound is instrumental in cancer research focused on targeting c-Met-associated pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
