Product Data Sheet
Columbamine chloride
Catalog No. A30419
Columbamine chloride is a quaternary isoquinoline alkaloid known for its biological activity as a cytochrome P450 (CYP) isoform CYP3A4 inhibitor, with an IC50 of 30.6 µM. This compound induces apoptosis in cancer cells and exhibits a range of biological effects, including antioxidant, anti-inflammatory, antitumor, antifungal, antiparasitic, hepatoprotective, neuroprotective, hypolipidemic, and hypoglycemic properties. Columbamine chloride is suitable for various research applications focusing on cancer biology, metabolic disorders, and neuroprotection.
Chemical Information
| Catalog Num | A30419 |
|---|---|
| M. Wt | 373.83 |
| Formula | C20H20ClNO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1916-10-5 |
| Synonyms | Columbamin chloride; Dehydroisocorypalmine chloride |
| SMILES | COC1=C(OC)C2=C[N+]3=C(C4=CC(O)=C(OC)C=C4CC3)C=C2C=C1.[Cl-] |
Biological Activity
| Description | Columbamine chloride is a quaternary isoquinoline alkaloid known for its biological activity as a cytochrome P450 (CYP) isoform CYP3A4 inhibitor, with an IC50 of 30.6 µM. This compound induces apoptosis in cancer cells and exhibits a range of biological effects, including antioxidant, anti-inflammatory, antitumor, antifungal, antiparasitic, hepatoprotective, neuroprotective, hypolipidemic, and hypoglycemic properties. Columbamine chloride is suitable for various research applications focusing on cancer biology, metabolic disorders, and neuroprotection. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
