Product Data Sheet
Polygalacin D
Catalog No. A30602
Polygalacin D (PGD) is an apoptosis inducer derived from Platycodon grandiflorum, exhibiting significant anticancer and anti-proliferative effects. It effectively downregulates inhibitor of apoptosis (IAP) proteins, including survivin, cIAP-1, and cIAP-2, while inhibiting the PI3K/Akt signaling pathway through the dephosphorylation of GSK3β and Akt, along with reduced expression of PI3K. PGD serves as a valuable reagent for research in cancer biology and therapeutic investigations targeting apoptosis mechanisms.
Chemical Information
| Catalog Num | A30602 |
|---|---|
| M. Wt | 1209.32 |
| Formula | C57H92O27 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 66663-91-0 |
| Synonyms | |
| SMILES | O[C@H]([C@@H]([C@@H](O[C@@]1([H])[C@@H]([C@H]([C@H](O)CO1)O[C@@]2([H])[C@@H]([C@](CO)(O)CO2)O)O)[C@H](C)O3)O)[C@]3([H])O[C@H]([C@H]([C@@H](O)CO4)O)[C@@H]4OC([C@]56[C@](CC(C)(C)CC6)([H])C7=CC[C@@]([C@@]8([C@@]([C@](C)([C@@H](O[C@]9([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]9O)CO)[C@@H](O)C8)CO)([H])CC%10)C)([H])[C@]%10(C)[C@]7(C)C[C@H]5O)=O |
Biological Activity
| Description | Polygalacin D (PGD) is an apoptosis inducer derived from Platycodon grandiflorum, exhibiting significant anticancer and anti-proliferative effects. It effectively downregulates inhibitor of apoptosis (IAP) proteins, including survivin, cIAP-1, and cIAP-2, while inhibiting the PI3K/Akt signaling pathway through the dephosphorylation of GSK3β and Akt, along with reduced expression of PI3K. PGD serves as a valuable reagent for research in cancer biology and therapeutic investigations targeting apoptosis mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
