Product Data Sheet
CDDO-TFEA
Catalog No. A30660
CDDO-TFEA is a trifluoroacetamide derivative of CDDO and serves as a potent Keap1-Nrf2 activator. This compound effectively enhances Nrf2 expression and signaling in various models of neurodegenerative diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. In cancer research, CDDO-TFEA demonstrates significant biological activity by inducing apoptosis and inhibiting colony formation in Ewing's sarcoma and neuroblastoma cell lines, with IC50 values ranging from 85 to 170 nM.
Chemical Information
| Catalog Num | A30660 |
|---|---|
| M. Wt | 572.70 |
| Formula | C33H43F3N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 932730-52-4 |
| Synonyms | CDDO-Trifluoethyl amide; RTA 404; TP-500 |
| SMILES | CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CCC(C)(C[C@]2([C@]13[H])[H])C)C(NCC(F)(F)F)=O)C)4C)5[H])C(C(C#N)=C[C@]5(C)C4=CC3=O)=O |
Biological Activity
| Description | CDDO-TFEA is a trifluoroacetamide derivative of CDDO and serves as a potent Keap1-Nrf2 activator. This compound effectively enhances Nrf2 expression and signaling in various models of neurodegenerative diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. In cancer research, CDDO-TFEA demonstrates significant biological activity by inducing apoptosis and inhibiting colony formation in Ewing's sarcoma and neuroblastoma cell lines, with IC50 values ranging from 85 to 170 nM. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
