Product Data Sheet
L-Asparagine-13C4,15N2 monohydrate
Catalog No. A30682
L-Asparagine-13C4,15N2 monohydrate is a stable isotope-labeled form of the amino acid L-Asparagine, incorporating four carbon-13 and two nitrogen-15 atoms. This compound serves as a key substrate for the enzyme L-Asparaginase, which is crucial in the treatment of leukemia by depleting asparagine levels and inhibiting cellular protein biosynthesis, particularly in lymphoblasts. Through asparagine elimination from the plasma, L-Asparaginase triggers suppression of RNA and DNA synthesis, leading to apoptosis in cancer cells, especially those with low expression of asparagine synthetase. L-Asparagine monohydrate can also serve as a valuable biomarker for research involving childhood acute lymphoblastic leukemia.
Chemical Information
| Catalog Num | A30682 |
|---|---|
| M. Wt | 156.09 |
| Formula | 13C4H1015N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 202406-87-9 |
| Synonyms | |
| SMILES | [15NH2][13C]([13CH2][13C@H]([15NH2])[13C](O)=O)=O.O |
Biological Activity
| Description | L-Asparagine-13C4,15N2 monohydrate is a stable isotope-labeled form of the amino acid L-Asparagine, incorporating four carbon-13 and two nitrogen-15 atoms. This compound serves as a key substrate for the enzyme L-Asparaginase, which is crucial in the treatment of leukemia by depleting asparagine levels and inhibiting cellular protein biosynthesis, particularly in lymphoblasts. Through asparagine elimination from the plasma, L-Asparaginase triggers suppression of RNA and DNA synthesis, leading to apoptosis in cancer cells, especially those with low expression of asparagine synthetase. L-Asparagine monohydrate can also serve as a valuable biomarker for research involving childhood acute lymphoblastic leukemia. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
