Product Data Sheet
Prinomastat hydrochloride
Catalog No. A30707
Prinomastat hydrochloride is a potent, orally active metalloproteinase (MMP) inhibitor that targets various MMPs, demonstrating IC50 values of 79 nM for MMP-1, 6.3 nM for MMP-3, and 5.0 nM for MMP-9. It exhibits high affinity, with Kis of 0.05 nM for MMP-2, 0.3 nM for MMP-3, 0.03 nM for MMP-13, and 0.26 nM for MMP-9, making it a broad-spectrum inhibitor. Notably, Prinomastat hydrochloride is capable of crossing the blood-brain barrier and has demonstrated antitumor activity, making it valuable for cancer research and therapeutic studies targeting MMP-related pathways.
Chemical Information
| Catalog Num | A30707 |
|---|---|
| M. Wt | 459.97 |
| Formula | C18H22ClN3O5S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1435779-45-5 |
| Synonyms | AG3340 hydrochloride; KB-R9896 hydrochloride |
| SMILES | O=C([C@@H]1N(S(=O)(C2=CC=C(OC3=CC=NC=C3)C=C2)=O)CCSC1(C)C)NO.[H]Cl |
Biological Activity
| Description | Prinomastat hydrochloride is a potent, orally active metalloproteinase (MMP) inhibitor that targets various MMPs, demonstrating IC50 values of 79 nM for MMP-1, 6.3 nM for MMP-3, and 5.0 nM for MMP-9. It exhibits high affinity, with Kis of 0.05 nM for MMP-2, 0.3 nM for MMP-3, 0.03 nM for MMP-13, and 0.26 nM for MMP-9, making it a broad-spectrum inhibitor. Notably, Prinomastat hydrochloride is capable of crossing the blood-brain barrier and has demonstrated antitumor activity, making it valuable for cancer research and therapeutic studies targeting MMP-related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
