Product Data Sheet
Temozolomide-d3
Catalog No. A30731
Temozolomide-d3 is a deuterium-labeled derivative of Temozolomide, a potent oral DNA alkylating agent that effectively penetrates the blood-brain barrier. This compound exerts proautophagic and proapoptotic effects, demonstrating significant cytotoxicity against tumor cells with deficient O6-alkylguanine DNA alkyltransferase (OGAT) and intact mismatch repair mechanisms. Additionally, Temozolomide exhibits both antitumor and antiangiogenic activities, making it valuable for research in cancer therapy and mechanisms of chemoresistance.
Chemical Information
| Catalog Num | A30731 |
|---|---|
| M. Wt | 197.17 |
| Formula | C6H3D3N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 208107-14-6 |
| Synonyms | |
| SMILES | O=C(N1C=N2)N(N=NC1=C2C(N)=O)C([2H])([2H])[2H] |
Biological Activity
| Description | Temozolomide-d3 is a deuterium-labeled derivative of Temozolomide, a potent oral DNA alkylating agent that effectively penetrates the blood-brain barrier. This compound exerts proautophagic and proapoptotic effects, demonstrating significant cytotoxicity against tumor cells with deficient O6-alkylguanine DNA alkyltransferase (OGAT) and intact mismatch repair mechanisms. Additionally, Temozolomide exhibits both antitumor and antiangiogenic activities, making it valuable for research in cancer therapy and mechanisms of chemoresistance. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
