Product Data Sheet
Nonactin
Catalog No. A30775
Nonactin is a macrotetrolide antibiotic that functions primarily as a mitochondrial uncoupler. It exhibits antibacterial, insecticidal, and acaricidal properties by acting as an ionophore for monovalent cations such as K+ and NH4+. Additionally, Nonactin inhibits the surface expression of endogenous HSP60 and can induce apoptosis in β-catenin mutant tumor cells, demonstrating its potential for anti-tumor applications. This compound is valuable for research in antibiotic resistance and cancer biology.
Chemical Information
| Catalog Num | A30775 |
|---|---|
| M. Wt | 736.93 |
| Formula | C40H64O12 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 6833-84-7 |
| Synonyms | Ammonium ionophore I |
| SMILES | O=C(O[C@H](C)C[C@@]1([H])CC[C@@](O1)([H])[C@H](C)C(O[C@@H](C)C[C@]2([H])CC[C@](O2)([H])[C@@H](C)C(O[C@H](C)C[C@@]3([H])CC[C@@](O3)([H])[C@@H]4C)=O)=O)[C@H](C)[C@@](O5)([H])CC[C@@]5([H])C[C@H](C)OC4=O |
Biological Activity
| Description | Nonactin is a macrotetrolide antibiotic that functions primarily as a mitochondrial uncoupler. It exhibits antibacterial, insecticidal, and acaricidal properties by acting as an ionophore for monovalent cations such as K+ and NH4+. Additionally, Nonactin inhibits the surface expression of endogenous HSP60 and can induce apoptosis in β-catenin mutant tumor cells, demonstrating its potential for anti-tumor applications. This compound is valuable for research in antibiotic resistance and cancer biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
