Product Data Sheet
Capmatinib dihydrochloride
Catalog No. A30789
Capmatinib dihydrochloride is a selective, ATP-competitive inhibitor of the c-MET kinase, exhibiting an IC50 of 0.13 nM. This compound effectively inhibits the phosphorylation of c-MET and its downstream effector pathways, including ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride demonstrates potent antitumor activity by suppressing c-MET-dependent tumor cell proliferation and migration, while also inducing apoptosis. The drug undergoes significant metabolism via CYP3A4 and aldehyde oxidase, making it relevant for studies involving c-MET-driven malignancies.
Chemical Information
| Catalog Num | A30789 |
|---|---|
| M. Wt | 485.34 |
| Formula | C23H19Cl2FN6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1197376-85-4 |
| Synonyms | INC280 dihydrochloride; INCB28060 dihydrochloride |
| SMILES | O=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F.Cl.Cl |
Biological Activity
| Description | Capmatinib dihydrochloride is a selective, ATP-competitive inhibitor of the c-MET kinase, exhibiting an IC50 of 0.13 nM. This compound effectively inhibits the phosphorylation of c-MET and its downstream effector pathways, including ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride demonstrates potent antitumor activity by suppressing c-MET-dependent tumor cell proliferation and migration, while also inducing apoptosis. The drug undergoes significant metabolism via CYP3A4 and aldehyde oxidase, making it relevant for studies involving c-MET-driven malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
