Product Data Sheet
Anagrelide
Catalog No. A30793
Anagrelide is a potent phosphodiesterase type III (PDE3) inhibitor with an IC50 of 36 nM. This imidazoquinazoline derivative effectively inhibits platelet aggregation and attenuates megakaryocytopoiesis in the bone marrow. Additionally, Anagrelide demonstrates the capacity to reduce proliferation and promote apoptosis in gastrointestinal stromal tumor (GIST) cells in vitro. Its primary application includes functioning as a platelet-lowering agent with significant antithrombopoietic properties.
Chemical Information
| Catalog Num | A30793 |
|---|---|
| M. Wt | 256.09 |
| Formula | C10H7Cl2N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 68475-42-3 |
| Synonyms | |
| SMILES | O=C1NC2=NC3=C(C(Cl)=C(Cl)C=C3)CN2C1 |
Biological Activity
| Description | Anagrelide is a potent phosphodiesterase type III (PDE3) inhibitor with an IC50 of 36 nM. This imidazoquinazoline derivative effectively inhibits platelet aggregation and attenuates megakaryocytopoiesis in the bone marrow. Additionally, Anagrelide demonstrates the capacity to reduce proliferation and promote apoptosis in gastrointestinal stromal tumor (GIST) cells in vitro. Its primary application includes functioning as a platelet-lowering agent with significant antithrombopoietic properties. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
