Product Data Sheet
Methotrexate-d3
Catalog No. A30799
Methotrexate-d3 is a deuterium-labeled form of Methotrexate, an antimetabolite and antifolate agent that selectively inhibits dihydrofolate reductase. This inhibition disrupts the conversion of folic acid to tetrahydrofolate, effectively blocking DNA synthesis. Methotrexate-d3 serves as a valuable tool in research applications related to rheumatoid arthritis and various cancers, including acute lymphoblastic leukemia, enabling studies on drug metabolism and therapeutic efficacy.
Chemical Information
| Catalog Num | A30799 |
|---|---|
| M. Wt | 457.46 |
| Formula | C20H19D3N8O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 432545-63-6 |
| Synonyms | |
| SMILES | NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)C([2H])([2H])[2H])C=N2 |
Biological Activity
| Description | Methotrexate-d3 is a deuterium-labeled form of Methotrexate, an antimetabolite and antifolate agent that selectively inhibits dihydrofolate reductase. This inhibition disrupts the conversion of folic acid to tetrahydrofolate, effectively blocking DNA synthesis. Methotrexate-d3 serves as a valuable tool in research applications related to rheumatoid arthritis and various cancers, including acute lymphoblastic leukemia, enabling studies on drug metabolism and therapeutic efficacy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
