Product Data Sheet
Diclofenac-d4 sodium
Catalog No. A30833
Diclofenac-d4 sodium is a deuterated form of the potent nonselective anti-inflammatory agent Diclofenac sodium, primarily targeting cyclooxygenase (COX) enzymes. It demonstrates effective COX inhibition, with IC50 values of 4 nM for human COX-1 and 1.3 nM for COX-2, along with 5.1 μM and 0.84 μM for ovine COX-1 and COX-2, respectively. This compound also induces apoptosis in neural stem cells through the activation of the caspase cascade, making it valuable for research in inflammation and neurobiology.
Chemical Information
| Catalog Num | A30833 |
|---|---|
| M. Wt | 322.16 |
| Formula | C14H6D4Cl2NNaO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 154523-54-3 |
| Synonyms | |
| SMILES | O=C(O[Na])CC(C([2H])=C([2H])C([2H])=C1[2H])=C1NC2=C(C=CC=C2Cl)Cl |
Biological Activity
| Description | Diclofenac-d4 sodium is a deuterated form of the potent nonselective anti-inflammatory agent Diclofenac sodium, primarily targeting cyclooxygenase (COX) enzymes. It demonstrates effective COX inhibition, with IC50 values of 4 nM for human COX-1 and 1.3 nM for COX-2, along with 5.1 μM and 0.84 μM for ovine COX-1 and COX-2, respectively. This compound also induces apoptosis in neural stem cells through the activation of the caspase cascade, making it valuable for research in inflammation and neurobiology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
