Product Data Sheet
5-NIdR
Catalog No. A30848
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) acts as an apoptosis inducer, demonstrating the capacity to inhibit DNA lesion replication caused by Temozolomide. This artificial nucleoside promotes apoptosis in cancer cells and effectively halts the cell cycle at the G0 phase. In preclinical studies, 5-NIdR has been shown to enhance the anti-tumor efficacy of Temozolomide in murine models of glioblastoma, providing valuable insights for cancer therapeutics research.
Chemical Information
| Catalog Num | A30848 |
|---|---|
| M. Wt | 278.26 |
| Formula | C13H14N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 191421-10-0 |
| Synonyms | 1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole |
| SMILES | O=[N+](C1=CC(C=CN2[C@@H]3O[C@H](CO)[C@@H](O)C3)=C2C=C1)[O-] |
Biological Activity
| Description | 5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) acts as an apoptosis inducer, demonstrating the capacity to inhibit DNA lesion replication caused by Temozolomide. This artificial nucleoside promotes apoptosis in cancer cells and effectively halts the cell cycle at the G0 phase. In preclinical studies, 5-NIdR has been shown to enhance the anti-tumor efficacy of Temozolomide in murine models of glioblastoma, providing valuable insights for cancer therapeutics research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
