Product Data Sheet
Acyclovir-d4
Catalog No. A30879
Acyclovir-d4 is a stable isotope labeled form of Acyclovir, a guanosine analogue recognized for its antiviral properties. Acyclovir exhibits potent inhibitory activity against herpes simplex virus types 1 and 2, exhibiting IC50 values of 0.85 μM and 0.86 μM, respectively, as well as effectiveness against varicella-zoster virus. Its mechanism of action involves phosphorylation by viral thymidine kinase, leading to the formation of Acyclovir triphosphate, which interferes with viral DNA polymerization by competing with guanosine triphosphate and causing chain termination. This compound is useful for studying viral infections and therapeutic interventions, particularly in the context of acute leukemia treatment.
Chemical Information
| Catalog Num | A30879 |
|---|---|
| M. Wt | 229.23 |
| Formula | C8H7D4N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1185179-33-2 |
| Synonyms | Aciclovir-d4; Acycloguanosine-d4 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2COC([2H])([2H])C([2H])([2H])O |
Biological Activity
| Description | Acyclovir-d4 is a stable isotope labeled form of Acyclovir, a guanosine analogue recognized for its antiviral properties. Acyclovir exhibits potent inhibitory activity against herpes simplex virus types 1 and 2, exhibiting IC50 values of 0.85 μM and 0.86 μM, respectively, as well as effectiveness against varicella-zoster virus. Its mechanism of action involves phosphorylation by viral thymidine kinase, leading to the formation of Acyclovir triphosphate, which interferes with viral DNA polymerization by competing with guanosine triphosphate and causing chain termination. This compound is useful for studying viral infections and therapeutic interventions, particularly in the context of acute leukemia treatment. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
