Product Data Sheet
Thalidomide-O-PEG2-propargyl
Catalog No. A30956
Thalidomide-O-PEG2-propargyl is a synthesized E3 ligase ligand-linker conjugate that targets cereblon, a key component of the E3 ubiquitin ligase complex. This compound incorporates a two-unit PEG linker and a propargyl group, making it suitable for click chemistry applications. Thalidomide-O-PEG2-propargyl can facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the conjugation of various azide-containing molecules, and is particularly useful in the development of targeted protein degradation strategies in chemical biology research.
Chemical Information
| Catalog Num | A30956 |
|---|---|
| M. Wt | 400.38 |
| Formula | C20H20N2O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2098487-52-4 |
| Synonyms | E3 ligase Ligand-Linker Conjugates 32 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCC#C)=O |
Biological Activity
| Description | Thalidomide-O-PEG2-propargyl is a synthesized E3 ligase ligand-linker conjugate that targets cereblon, a key component of the E3 ubiquitin ligase complex. This compound incorporates a two-unit PEG linker and a propargyl group, making it suitable for click chemistry applications. Thalidomide-O-PEG2-propargyl can facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the conjugation of various azide-containing molecules, and is particularly useful in the development of targeted protein degradation strategies in chemical biology research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
