Product Data Sheet
Thalidomide-O-amido-C4-NH2 hydrochloride
Catalog No. A31077
Thalidomide-O-amido-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that incorporates a cereblon ligand derived from Thalidomide. This compound is primarily utilized in the development of PROTACs (proteolysis targeting chimeras), enabling targeted protein degradation. Its unique structure facilitates the recruitment of cognate E3 ligases, thereby promoting the efficient ubiquitination and subsequent degradation of specific target proteins, making it a valuable tool in chemical biology and therapeutic research.
Chemical Information
| Catalog Num | A31077 |
|---|---|
| M. Wt | 438.86 |
| Formula | C19H23ClN4O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2245697-86-1 |
| Synonyms | |
| SMILES | NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O.Cl |
Biological Activity
| Description | Thalidomide-O-amido-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that incorporates a cereblon ligand derived from Thalidomide. This compound is primarily utilized in the development of PROTACs (proteolysis targeting chimeras), enabling targeted protein degradation. Its unique structure facilitates the recruitment of cognate E3 ligases, thereby promoting the efficient ubiquitination and subsequent degradation of specific target proteins, making it a valuable tool in chemical biology and therapeutic research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
