Product Data Sheet
Columbamine
Catalog No. A31145
Columbamine is a quaternary isoquinoline alkaloid that acts primarily by inhibiting the cytochrome P450 isoform CYP3A4, with an IC50 of 30.6 µM. This compound demonstrates significant biological activities, including the induction of apoptosis in cancer cells, as well as antioxidant, anti-inflammatory, antitumor, antifungal, antiparasitic, hepatoprotective, neuroprotective, hypolipidemic, and hypoglycemic effects. It is suitable for various research applications exploring therapeutic interventions and mechanisms in cancer and metabolic diseases.
Chemical Information
| Catalog Num | A31145 |
|---|---|
| M. Wt | 338.38 |
| Formula | C20H20NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3621-36-1 |
| Synonyms | Columbamin; Dehydroisocorypalmine |
| SMILES | COC1=C(OC)C2=C[N+]3=C(C4=CC(O)=C(OC)C=C4CC3)C=C2C=C1 |
Biological Activity
| Description | Columbamine is a quaternary isoquinoline alkaloid that acts primarily by inhibiting the cytochrome P450 isoform CYP3A4, with an IC50 of 30.6 µM. This compound demonstrates significant biological activities, including the induction of apoptosis in cancer cells, as well as antioxidant, anti-inflammatory, antitumor, antifungal, antiparasitic, hepatoprotective, neuroprotective, hypolipidemic, and hypoglycemic effects. It is suitable for various research applications exploring therapeutic interventions and mechanisms in cancer and metabolic diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
