Product Data Sheet
Pitavastatin sodium
Catalog No. A31160
Pitavastatin sodium is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, significantly reducing cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. This compound serves as an effective inducer of low-density lipoprotein-cholesterol (LDL-C) receptors in hepatocytes. In addition to its primary role in cholesterol regulation, pitavastatin sodium exhibits various biological activities, including anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects, making it valuable for diverse research applications in lipid metabolism and disease.
Chemical Information
| Catalog Num | A31160 |
|---|---|
| M. Wt | 443.44 |
| Formula | C25H23FNNaO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 574705-92-3 |
| Synonyms | NK-104 sodium |
| SMILES | O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(C=C2)F)C3=C(C=CC=C3)N=C1C4CC4 |
Biological Activity
| Description | Pitavastatin sodium is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, significantly reducing cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. This compound serves as an effective inducer of low-density lipoprotein-cholesterol (LDL-C) receptors in hepatocytes. In addition to its primary role in cholesterol regulation, pitavastatin sodium exhibits various biological activities, including anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects, making it valuable for diverse research applications in lipid metabolism and disease. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
