Product Data Sheet
Brazilein
Catalog No. A31162
Brazilein is an anti-inflammatory agent that targets Na+,K+-ATPase with an IC50 of 500 μM. It exhibits potent neuroprotective activities by reducing iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells and modulating inflammatory cytokines such as TNF-α and IL-6. Brazilein has been shown to decrease cerebral infarction volume and enhance neurological function in models of cerebral ischemia-reperfusion injury. Additionally, it induces apoptosis in splenic lymphocytes and can affect immune responses and organ weights, making it valuable for research in neurobiology, cardiovascular health, and inflammatory disorders.
Chemical Information
| Catalog Num | A31162 |
|---|---|
| M. Wt | 284.26 |
| Formula | C16H12O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 600-76-0 |
| Synonyms | |
| SMILES | O=C1C=C2C(C=C1O)=C3C4=C(OCC3(C2)O)C=C(O)C=C4 |
Biological Activity
| Description | Brazilein is an anti-inflammatory agent that targets Na+,K+-ATPase with an IC50 of 500 μM. It exhibits potent neuroprotective activities by reducing iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells and modulating inflammatory cytokines such as TNF-α and IL-6. Brazilein has been shown to decrease cerebral infarction volume and enhance neurological function in models of cerebral ischemia-reperfusion injury. Additionally, it induces apoptosis in splenic lymphocytes and can affect immune responses and organ weights, making it valuable for research in neurobiology, cardiovascular health, and inflammatory disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
