Product Data Sheet
Cabozantinib-d4
Catalog No. A31181
Cabozantinib-d4 is a deuterium-labeled analog of Cabozantinib, which functions as a potent inhibitor of multiple receptor tyrosine kinases (RTKs). It exhibits significant inhibition of VEGFR2, c-Met, Kit, Axl, and Flt3 with IC50 values of 0.035 nM, 1.3 nM, 4.6 nM, 7 nM, and 11.3 nM, respectively. This stabilized isotope is valuable for pharmacokinetic and metabolic studies, enabling researchers to trace and analyze the drug's metabolic pathways and interactions in biological systems.
Chemical Information
| Catalog Num | A31181 |
|---|---|
| M. Wt | 505.53 |
| Formula | C28H20D4FN3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1802168-53-1 |
| Synonyms | XL184-d4; BMS-907351-d4 |
| SMILES | COC(C(OC)=C1)=CC2=C1C(OC(C=C3)=CC=C3NC(C4(CC4)C(NC5=C([2H])C([2H])=C(C([2H])=C5[2H])F)=O)=O)=CC=N2 |
Biological Activity
| Description | Cabozantinib-d4 is a deuterium-labeled analog of Cabozantinib, which functions as a potent inhibitor of multiple receptor tyrosine kinases (RTKs). It exhibits significant inhibition of VEGFR2, c-Met, Kit, Axl, and Flt3 with IC50 values of 0.035 nM, 1.3 nM, 4.6 nM, 7 nM, and 11.3 nM, respectively. This stabilized isotope is valuable for pharmacokinetic and metabolic studies, enabling researchers to trace and analyze the drug's metabolic pathways and interactions in biological systems. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
