Product Data Sheet
Tolcapone-d4
Catalog No. A31211
Tolcapone-d4 is a deuterated derivative of the selective catechol-O-methyltransferase (COMT) inhibitor, Tolcapone. This compound exhibits an IC50 of 773 nM, demonstrating its potency in inhibiting COMT activity. Tolcapone-d4 is utilized in research related to neurodegenerative disorders and cancer, as it influences α-synuclein and amyloid-beta oligomerization and fibrillogenesis. Additionally, it has been shown to induce oxidative stress, promote apoptosis in cancer cells, and increase reactive oxygen species (ROS) production, making it valuable for studies in both cancer and neurological disease contexts.
Chemical Information
| Catalog Num | A31211 |
|---|---|
| M. Wt | 277.27 |
| Formula | C14H7D4NO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1246816-93-2 |
| Synonyms | Ro 40-7592-d4 |
| SMILES | O=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])C)C2=CC([N+]([O-])=O)=C(C(O)=C2)O |
Biological Activity
| Description | Tolcapone-d4 is a deuterated derivative of the selective catechol-O-methyltransferase (COMT) inhibitor, Tolcapone. This compound exhibits an IC50 of 773 nM, demonstrating its potency in inhibiting COMT activity. Tolcapone-d4 is utilized in research related to neurodegenerative disorders and cancer, as it influences α-synuclein and amyloid-beta oligomerization and fibrillogenesis. Additionally, it has been shown to induce oxidative stress, promote apoptosis in cancer cells, and increase reactive oxygen species (ROS) production, making it valuable for studies in both cancer and neurological disease contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
