Product Data Sheet
Prexasertib Mesylate Hydrate
Catalog No. A31220
Prexasertib Mesylate Hydrate is a selective, ATP-competitive inhibitor of checkpoint kinase 1 (CHK1) with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits checkpoint kinase 2 (CHK2) with an IC50 of 8 nM and ribosomal S6 kinase 1 (RSK1) with an IC50 of 9 nM. By inducing double-stranded DNA breakage and replication catastrophe, Prexasertib Mesylate Hydrate promotes apoptotic cell death, exhibiting significant anti-tumor activity. This reagent is primarily utilized in cancer research to explore mechanisms of DNA damage response and therapeutic resistance.
Chemical Information
| Catalog Num | A31220 |
|---|---|
| M. Wt | 479.51 |
| Formula | C19H25N7O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1234015-57-6 |
| Synonyms | LY2606368 Mesylate Hydrate; LY2940930 |
| SMILES | N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1.CS(=O)(O)=O.O |
Biological Activity
| Description | Prexasertib Mesylate Hydrate is a selective, ATP-competitive inhibitor of checkpoint kinase 1 (CHK1) with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits checkpoint kinase 2 (CHK2) with an IC50 of 8 nM and ribosomal S6 kinase 1 (RSK1) with an IC50 of 9 nM. By inducing double-stranded DNA breakage and replication catastrophe, Prexasertib Mesylate Hydrate promotes apoptotic cell death, exhibiting significant anti-tumor activity. This reagent is primarily utilized in cancer research to explore mechanisms of DNA damage response and therapeutic resistance. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
