Product Data Sheet
DB1976
Catalog No. A31230
DB1976 is a potent PU.1 inhibitor, functioning through the disruption of PU.1 binding to DNA. With an IC50 of 10 nM, it effectively prevents the formation of the PU.1/DNA complex, exhibiting a high affinity (KD of 12 nM) in vitro. This compound demonstrates the ability to induce apoptosis, making it a valuable tool for research applications targeting transcriptional regulation and cellular apoptosis pathways.
Chemical Information
| Catalog Num | A31230 |
|---|---|
| M. Wt | 447.35 |
| Formula | C20H16N8Se |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1557397-51-9 |
| Synonyms | |
| SMILES | N=C(C1=CC=C2N=C(C3=CC=C(C4=NC5=CC=C(C(N)=N)C=C5N4)[Se]3)NC2=C1)N |
Biological Activity
| Description | DB1976 is a potent PU.1 inhibitor, functioning through the disruption of PU.1 binding to DNA. With an IC50 of 10 nM, it effectively prevents the formation of the PU.1/DNA complex, exhibiting a high affinity (KD of 12 nM) in vitro. This compound demonstrates the ability to induce apoptosis, making it a valuable tool for research applications targeting transcriptional regulation and cellular apoptosis pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
