Product Data Sheet
Thalidomide-4-O-C8-NH2 hydrochloride
Catalog No. A31259
Thalidomide-4-O-C8-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate featuring the cereblon ligand derived from thalidomide, combined with a C8 linker. This compound is designed for use in PROTAC technology, facilitating the targeted degradation of proteins via the ubiquitin-proteasome pathway. Its application in chemical biology includes studies of protein modulation and therapeutic strategies in oncology and other disease models, enabling researchers to explore novel approaches in targeted protein degradation.
Chemical Information
| Catalog Num | A31259 |
|---|---|
| M. Wt | 437.92 |
| Formula | C21H28ClN3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2636798-38-2 |
| Synonyms | |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCCCCN)=O.[H]Cl |
Biological Activity
| Description | Thalidomide-4-O-C8-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate featuring the cereblon ligand derived from thalidomide, combined with a C8 linker. This compound is designed for use in PROTAC technology, facilitating the targeted degradation of proteins via the ubiquitin-proteasome pathway. Its application in chemical biology includes studies of protein modulation and therapeutic strategies in oncology and other disease models, enabling researchers to explore novel approaches in targeted protein degradation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
