Product Data Sheet
Thalidomide-O-PEG4-amine
Catalog No. A31344
Thalidomide-O-PEG4-amine is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology. This compound combines the Thalidomide-derived ligand, which targets cereblon, with a PEG4 linker to facilitate the development of bifunctional degraders. Its primary application lies in the degradation of target proteins, enabling novel therapeutic strategies in cancer and other diseases by harnessing the ubiquitin-proteasome system.
Chemical Information
| Catalog Num | A31344 |
|---|---|
| M. Wt | 493.51 |
| Formula | C23H31N3O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2401832-00-4 |
| Synonyms | |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCN)=O |
Biological Activity
| Description | Thalidomide-O-PEG4-amine is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology. This compound combines the Thalidomide-derived ligand, which targets cereblon, with a PEG4 linker to facilitate the development of bifunctional degraders. Its primary application lies in the degradation of target proteins, enabling novel therapeutic strategies in cancer and other diseases by harnessing the ubiquitin-proteasome system. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
