Product Data Sheet
Thalidomide-NH-C8-NH2 hydrochloride
Catalog No. A31354
Thalidomide-NH-C8-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that features a Thalidomide-derived cereblon ligand paired with a C8 linker. This compound is designed for use in PROTAC (Proteolysis Targeting Chimera) applications, facilitating targeted protein degradation through the induction of ubiquitin-proteasome pathway involvement. Its unique structure allows for efficient cellular uptake and modulation of specific protein levels, making it invaluable for research in cellular signaling, disease modeling, and therapeutic development.
Chemical Information
| Catalog Num | A31354 |
|---|---|
| M. Wt | 436.93 |
| Formula | C21H29ClN4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2446474-06-0 |
| Synonyms | |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCCCN)=O.[H]Cl |
Biological Activity
| Description | Thalidomide-NH-C8-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that features a Thalidomide-derived cereblon ligand paired with a C8 linker. This compound is designed for use in PROTAC (Proteolysis Targeting Chimera) applications, facilitating targeted protein degradation through the induction of ubiquitin-proteasome pathway involvement. Its unique structure allows for efficient cellular uptake and modulation of specific protein levels, making it invaluable for research in cellular signaling, disease modeling, and therapeutic development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
