Product Data Sheet
L-Asparagine-amide-15N monohydrate
Catalog No. A31420
L-Asparagine-amide-15N monohydrate is a stable isotope-labeled form of the amino acid L-Asparagine. It serves as an essential substrate for L-Asparaginase, an enzyme that depletes asparagine and glutamine levels, ultimately inhibiting protein biosynthesis in leukemic cells. This compound is instrumental in research applications targeting childhood acute lymphoblastic leukemia, where the depletion of asparagine leads to inhibited RNA and DNA synthesis, promoting apoptosis in cancer cells with low asparagine synthetase expression. Additionally, L-Asparagine monohydrate functions as a valuable biomarker and sensor in studies of leukemic cell metabolism.
Chemical Information
| Catalog Num | A31420 |
|---|---|
| M. Wt | 151.13 |
| Formula | C4H10N15NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 204451-47-8 |
| Synonyms | |
| SMILES | [15NH2]C(C[C@H](N)C(O)=O)=O.[H]O[H] |
Biological Activity
| Description | L-Asparagine-amide-15N monohydrate is a stable isotope-labeled form of the amino acid L-Asparagine. It serves as an essential substrate for L-Asparaginase, an enzyme that depletes asparagine and glutamine levels, ultimately inhibiting protein biosynthesis in leukemic cells. This compound is instrumental in research applications targeting childhood acute lymphoblastic leukemia, where the depletion of asparagine leads to inhibited RNA and DNA synthesis, promoting apoptosis in cancer cells with low asparagine synthetase expression. Additionally, L-Asparagine monohydrate functions as a valuable biomarker and sensor in studies of leukemic cell metabolism. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
