Product Data Sheet
Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE
Catalog No. A31432
Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It features a linker alongside the potent cytotoxic agent MMAE, enabling targeted delivery to cells expressing the c-Kit receptor. This compound can facilitate the synthesis of NN3201 by conjugating with NN2101 (anti c-Kit), which promotes rapid internalization and effectively disrupts SCF-driven signaling pathways. Consequently, NN3201 demonstrates significant anti-tumor activity in various cancer models, including small cell lung cancer (SCLC) and gastrointestinal stromal tumors (GIST).
Chemical Information
| Catalog Num | A31432 |
|---|---|
| M. Wt | 2805.41 |
| Formula | C137H222N12O44S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3103526-19-5 |
| Synonyms | |
| SMILES | O=C(OCC1=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CC[C@H](NC(C2=CC=C(C(C(CS(=O)(C3=CC=C(C)C=C3)=O)CS(=O)(C4=CC=C(C)C=C4)=O)=O)C=C2)=O)C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)=O)=O)C=C1)N([C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N5[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C6=CC=CC=C6)=O)CCC5)=O)C)=O)=O)C |
Biological Activity
| Description | Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It features a linker alongside the potent cytotoxic agent MMAE, enabling targeted delivery to cells expressing the c-Kit receptor. This compound can facilitate the synthesis of NN3201 by conjugating with NN2101 (anti c-Kit), which promotes rapid internalization and effectively disrupts SCF-driven signaling pathways. Consequently, NN3201 demonstrates significant anti-tumor activity in various cancer models, including small cell lung cancer (SCLC) and gastrointestinal stromal tumors (GIST). |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
