Product Data Sheet
Palmatine
Catalog No. A31433
Palmatine is a selective, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), exhibiting IC50 values of 3 μM against HEK 293-hIDO-1 and 157 μM against rhIDO-1. Additionally, Palmatine effectively inhibits the West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. This compound demonstrates diverse biological activities including anti-cancer, anti-oxidation, anti-inflammatory, neuroprotective, antibacterial, and antiviral effects, making it a valuable tool for research in cancer biology, inflammation, and infectious diseases.
Chemical Information
| Catalog Num | A31433 |
|---|---|
| M. Wt | 352.40 |
| Formula | C21H22NO4+ |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3486-67-7 |
| Synonyms | |
| SMILES | COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(OC)C=C4CC3)C=C2C=C1 |
Biological Activity
| Description | Palmatine is a selective, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), exhibiting IC50 values of 3 μM against HEK 293-hIDO-1 and 157 μM against rhIDO-1. Additionally, Palmatine effectively inhibits the West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. This compound demonstrates diverse biological activities including anti-cancer, anti-oxidation, anti-inflammatory, neuroprotective, antibacterial, and antiviral effects, making it a valuable tool for research in cancer biology, inflammation, and infectious diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
