Product Data Sheet
FC-116
Catalog No. A31434
FC-116 is a potent tubulin inhibitor that disrupts microtubule dynamics, leading to the inhibition of colorectal cancer (CRC) cell proliferation. It demonstrates significant activity with IC50 values of 4.52 nM in HCT116 cells and 18.69 nM in CT26 cells. By inducing endoplasmic reticulum stress and generating excess reactive oxygen species (ROS), FC-116 promotes mitochondrial damage and apoptosis in CRC cells. This compound also exhibits substantial anti-tumor effects in vivo, making it a valuable reagent for colorectal cancer research.
Chemical Information
| Catalog Num | A31434 |
|---|---|
| M. Wt | 369.39 |
| Formula | C21H20FNO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2417298-29-2 |
| Synonyms | |
| SMILES | COC1=C(OC)C(OC)=CC(C(/C(C)=C/C2=CNC3=C2C=CC(F)=C3)=O)=C1 |
Biological Activity
| Description | FC-116 is a potent tubulin inhibitor that disrupts microtubule dynamics, leading to the inhibition of colorectal cancer (CRC) cell proliferation. It demonstrates significant activity with IC50 values of 4.52 nM in HCT116 cells and 18.69 nM in CT26 cells. By inducing endoplasmic reticulum stress and generating excess reactive oxygen species (ROS), FC-116 promotes mitochondrial damage and apoptosis in CRC cells. This compound also exhibits substantial anti-tumor effects in vivo, making it a valuable reagent for colorectal cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
