Product Data Sheet
Sunitinib-d10
Catalog No. A31451
Sunitinib-d10 is a deuterium-labeled variant of Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor that primarily targets VEGFR2 and PDGFRβ with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, Sunitinib-d10 effectively blocks autophosphorylation of Ire1α, thereby inhibiting its RNase activity. This stable isotope is utilized in pharmacokinetic studies and metabolic labeling, facilitating deeper insights into kinase signaling pathways and drug metabolism.
Chemical Information
| Catalog Num | A31451 |
|---|---|
| M. Wt | 408.54 |
| Formula | C22H17D10FN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1126721-82-1 |
| Synonyms | SU 11248-d10 |
| SMILES | O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H] |
Biological Activity
| Description | Sunitinib-d10 is a deuterium-labeled variant of Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor that primarily targets VEGFR2 and PDGFRβ with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, Sunitinib-d10 effectively blocks autophosphorylation of Ire1α, thereby inhibiting its RNase activity. This stable isotope is utilized in pharmacokinetic studies and metabolic labeling, facilitating deeper insights into kinase signaling pathways and drug metabolism. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
