Product Data Sheet
L-Asparagine-13C4,15N2,d3 monohydrate
Catalog No. A31495
L-Asparagine-13C4,15N2,d3 monohydrate is a stable isotope-labeled form of L-Asparagine, featuring deuterium, 13C, and 15N isotopes. This amino acid is critical for leukemic cell survival and serves as a substrate for the enzyme L-Asparaginase, which induces asparagine and glutamine depletion. The action of L-Asparaginase notably disrupts RNA and DNA synthesis, leading to apoptosis in lymphoblasts, particularly affecting cells with low asparagine synthetase expression. L-Asparagine-13C4,15N2,d3 monohydrate is a valuable tool for research into acute lymphoblastic leukemia, aiding in biomarker studies and the development of targeted therapies.
Chemical Information
| Catalog Num | A31495 |
|---|---|
| M. Wt | 159.11 |
| Formula | 13C4H7D3 15N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2483829-30-5 |
| Synonyms | |
| SMILES | [15NH2][13C]([13C]([2H])([2H])[13C@@]([15NH2])([2H])[13C](O)=O)=O.O |
Biological Activity
| Description | L-Asparagine-13C4,15N2,d3 monohydrate is a stable isotope-labeled form of L-Asparagine, featuring deuterium, 13C, and 15N isotopes. This amino acid is critical for leukemic cell survival and serves as a substrate for the enzyme L-Asparaginase, which induces asparagine and glutamine depletion. The action of L-Asparaginase notably disrupts RNA and DNA synthesis, leading to apoptosis in lymphoblasts, particularly affecting cells with low asparagine synthetase expression. L-Asparagine-13C4,15N2,d3 monohydrate is a valuable tool for research into acute lymphoblastic leukemia, aiding in biomarker studies and the development of targeted therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
