Product Data Sheet
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
Catalog No. A31515
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate targeting cereblon, a key component in the ubiquitin-proteasome pathway. This compound is designed to facilitate targeted protein degradation through PROTAC technology, enabling researchers to manipulate cellular protein levels with high specificity. Its unique linker structure enhances the conjugate’s stability and efficacy in various biological applications, making it a valuable tool for studying protein regulation and therapeutic interventions.
Chemical Information
| Catalog Num | A31515 |
|---|---|
| M. Wt | 534.56 |
| Formula | C25H34N4O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2435572-48-6 |
| Synonyms | Cereblon Ligand-Linker Conjugates 12; E3 Ligase Ligand-Linker Conjugates 23 |
| SMILES | O=C(NCCOCCCOCCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O |
Biological Activity
| Description | Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate targeting cereblon, a key component in the ubiquitin-proteasome pathway. This compound is designed to facilitate targeted protein degradation through PROTAC technology, enabling researchers to manipulate cellular protein levels with high specificity. Its unique linker structure enhances the conjugate’s stability and efficacy in various biological applications, making it a valuable tool for studying protein regulation and therapeutic interventions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
