Product Data Sheet
Thalidomide-NH-C4-NH2 TFA
Catalog No. A31523
Thalidomide-NH-C4-NH2 TFA is an E3 ligase ligand-linker conjugate that features a thalidomide-derived cereblon ligand attached to a linker. This compound serves as a critical component in the development of PROTAC BRD2/BRD4 degrader-1, which effectively degrades the BET proteins BRD4 and BRD2. Its utility in this context highlights its potential in targeted protein degradation research and therapeutic applications.
Chemical Information
| Catalog Num | A31523 |
|---|---|
| M. Wt | 458.39 |
| Formula | C19H21F3N4O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2093387-50-7 |
| Synonyms | |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCN)=O.O=C(O)C(F)(F)F |
Biological Activity
| Description | Thalidomide-NH-C4-NH2 TFA is an E3 ligase ligand-linker conjugate that features a thalidomide-derived cereblon ligand attached to a linker. This compound serves as a critical component in the development of PROTAC BRD2/BRD4 degrader-1, which effectively degrades the BET proteins BRD4 and BRD2. Its utility in this context highlights its potential in targeted protein degradation research and therapeutic applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
