Product Data Sheet
Thalidomide-O-amido-C3-NH2
Catalog No. A31525
Thalidomide-O-amido-C3-NH2 is an E3 ligase ligand-linker conjugate that features a cereblon ligand derived from thalidomide, combined with a linker suitable for PROTAC technology. This compound facilitates targeted protein degradation by promoting the ubiquitination of specific substrates through interactions with the ubiquitin-proteasome system. It is widely utilized in research applications focused on the development and optimization of PROTACs for therapeutic interventions in various diseases.
Chemical Information
| Catalog Num | A31525 |
|---|---|
| M. Wt | 388.37 |
| Formula | C18H20N4O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2022182-57-4 |
| Synonyms | Cereblon Ligand-Linker Conjugates 16; E3 Ligase Ligand-Linker Conjugates 52 |
| SMILES | O=C(NCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O |
Biological Activity
| Description | Thalidomide-O-amido-C3-NH2 is an E3 ligase ligand-linker conjugate that features a cereblon ligand derived from thalidomide, combined with a linker suitable for PROTAC technology. This compound facilitates targeted protein degradation by promoting the ubiquitination of specific substrates through interactions with the ubiquitin-proteasome system. It is widely utilized in research applications focused on the development and optimization of PROTACs for therapeutic interventions in various diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
