Product Data Sheet
PF-543 hydrochloride
Catalog No. A31532
PF-543 hydrochloride is a potent and selective inhibitor of Sphingosine Kinase 1 (SPHK1), exhibiting an IC50 of 2 nM and a Ki of 3.6 nM. It demonstrates over 100-fold selectivity for SPHK1 compared to SPHK2, making it a valuable tool for studying sphingosine-mediated signaling pathways. PF-543 hydrochloride effectively inhibits the formation of sphingosine 1-phosphate (S1P) in whole blood with an IC50 of 26.7 nM, and it has been shown to induce apoptosis, necrosis, and autophagy in various cell types, highlighting its potential in cancer and therapeutic research applications.
Chemical Information
| Catalog Num | A31532 |
|---|---|
| M. Wt | 502.07 |
| Formula | C27H32ClNO4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1706522-79-3 |
| Synonyms | Sphingosine Kinase 1 Inhibitor II hydrochloride |
| SMILES | [H]Cl.O=S(C1=CC=CC=C1)(CC2=CC(C)=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=C2)=O |
Biological Activity
| Description | PF-543 hydrochloride is a potent and selective inhibitor of Sphingosine Kinase 1 (SPHK1), exhibiting an IC50 of 2 nM and a Ki of 3.6 nM. It demonstrates over 100-fold selectivity for SPHK1 compared to SPHK2, making it a valuable tool for studying sphingosine-mediated signaling pathways. PF-543 hydrochloride effectively inhibits the formation of sphingosine 1-phosphate (S1P) in whole blood with an IC50 of 26.7 nM, and it has been shown to induce apoptosis, necrosis, and autophagy in various cell types, highlighting its potential in cancer and therapeutic research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
