Product Data Sheet
Ruxolitinib-d9
Catalog No. A31551
Ruxolitinib-d9 is a deuterium-labeled derivative of Ruxolitinib, a selective JAK1/2 inhibitor. With IC50 values of 3.3 nM and 2.8 nM for JAK1 and JAK2 respectively, Ruxolitinib demonstrates a significant preference for these targets over JAK3, exhibiting a 130-fold selectivity. This compound plays a critical role in cancer research by inducing autophagy and promoting cell death in tumor cells through mechanisms of toxic mitophagy.
Chemical Information
| Catalog Num | A31551 |
|---|---|
| M. Wt | 315.42 |
| Formula | C17H9D9N6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1513883-55-0 |
| Synonyms | INCB18424-d9 |
| SMILES | N#CC[C@H](C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H])N2C=C(C=N2)C3=C4C(NC=C4)=NC=N3 |
Biological Activity
| Description | Ruxolitinib-d9 is a deuterium-labeled derivative of Ruxolitinib, a selective JAK1/2 inhibitor. With IC50 values of 3.3 nM and 2.8 nM for JAK1 and JAK2 respectively, Ruxolitinib demonstrates a significant preference for these targets over JAK3, exhibiting a 130-fold selectivity. This compound plays a critical role in cancer research by inducing autophagy and promoting cell death in tumor cells through mechanisms of toxic mitophagy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
