Product Data Sheet
Antiproliferative agent-23
Catalog No. A31605
Antiproliferative agent-23 is a microtubule-destabilizing agent that disrupts the tubulin-microtubule system. It induces apoptosis through a mitochondrion-dependent mechanism by downregulating Bcl-2, while upregulating Bax and Cyt c proteins, thereby activating the caspase cascade. Additionally, antiproliferative agent-23 triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells via the PERK/ATF4/CHOP signaling pathway, demonstrating significant anti-tumor activity. This compound is suitable for research applications aimed at understanding cancer biology and therapeutic interventions.
Chemical Information
| Catalog Num | A31605 |
|---|---|
| M. Wt | 743.93 |
| Formula | C23H28Cl3N3O6Pt |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3049213-47-7 |
| Synonyms | |
| SMILES | O=C(C1=CC(OC)=C(C(OC)=C1)OC)/C=C/C2=CC=CC3=C2C=CN3CCC(O[Pt](Cl)(Cl)(Cl)([NH3])[NH3])=O |
Biological Activity
| Description | Antiproliferative agent-23 is a microtubule-destabilizing agent that disrupts the tubulin-microtubule system. It induces apoptosis through a mitochondrion-dependent mechanism by downregulating Bcl-2, while upregulating Bax and Cyt c proteins, thereby activating the caspase cascade. Additionally, antiproliferative agent-23 triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells via the PERK/ATF4/CHOP signaling pathway, demonstrating significant anti-tumor activity. This compound is suitable for research applications aimed at understanding cancer biology and therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
