Product Data Sheet
Tegaserod-d11
Catalog No. A31717
Tegaserod-d11 is a deuterated analog of Tegaserod, a selective agonist of the serotonin receptor 4 (HTR4) and a potent antagonist of the 5-HT2B receptor. With pKis of 7.5, 8.4, and 7.0 for the human recombinant 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively, Tegaserod exhibits significant biological activity by inducing tumor cell apoptosis, inhibiting PI3K/Akt/mTOR signaling, and reducing S6 phosphorylation. This reagent is valuable for research applications focusing on anti-tumor effects and the pathophysiology of irritable bowel syndrome (IBS).
Chemical Information
| Catalog Num | A31717 |
|---|---|
| M. Wt | 312.45 |
| Formula | C16H12D11N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1134188-56-9 |
| Synonyms | |
| SMILES | N=C(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])N/N=C/C1=CNC2=CC=C(OC)C=C21 |
Biological Activity
| Description | Tegaserod-d11 is a deuterated analog of Tegaserod, a selective agonist of the serotonin receptor 4 (HTR4) and a potent antagonist of the 5-HT2B receptor. With pKis of 7.5, 8.4, and 7.0 for the human recombinant 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively, Tegaserod exhibits significant biological activity by inducing tumor cell apoptosis, inhibiting PI3K/Akt/mTOR signaling, and reducing S6 phosphorylation. This reagent is valuable for research applications focusing on anti-tumor effects and the pathophysiology of irritable bowel syndrome (IBS). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
