Product Data Sheet
2-Methoxyjuglone
Catalog No. A31728
2-Methoxyjuglone is a naphthoquinone that functions primarily as an apoptosis inducer. It activates caspase-9 and caspase-3 through the mitochondrial cytochrome c-dependent intrinsic apoptosis pathway, leading to increased pro-apoptotic Bax levels and decreased anti-apoptotic Bcl-2 levels. 2-Methoxyjuglone also induces apoptosis by promoting mitochondrial cytochrome c release and is associated with morphological changes of apoptosis, early apoptotic signals, cell cycle arrest in S-phase and G2/M-phase, as well as DNA double-strand breaks. Additionally, it exhibits antimicrobial properties against Gram-positive bacteria and pathogenic fungi, making it valuable in the research of various cancers, including hepatocellular carcinoma and breast cancer, as well as in studies of fungal and bacterial infections.
Chemical Information
| Catalog Num | A31728 |
|---|---|
| M. Wt | 204.18 |
| Formula | C11H8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 15127-94-3 |
| Synonyms | |
| SMILES | O=C1C=C(C(C2=C1C(O)=CC=C2)=O)OC |
Biological Activity
| Description | 2-Methoxyjuglone is a naphthoquinone that functions primarily as an apoptosis inducer. It activates caspase-9 and caspase-3 through the mitochondrial cytochrome c-dependent intrinsic apoptosis pathway, leading to increased pro-apoptotic Bax levels and decreased anti-apoptotic Bcl-2 levels. 2-Methoxyjuglone also induces apoptosis by promoting mitochondrial cytochrome c release and is associated with morphological changes of apoptosis, early apoptotic signals, cell cycle arrest in S-phase and G2/M-phase, as well as DNA double-strand breaks. Additionally, it exhibits antimicrobial properties against Gram-positive bacteria and pathogenic fungi, making it valuable in the research of various cancers, including hepatocellular carcinoma and breast cancer, as well as in studies of fungal and bacterial infections. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
