Product Data Sheet
KRC-108
Catalog No. A31745
KRC-108 is a potent aminopyridine that functions as a multiple kinase inhibitor, targeting c-Met and its variants, Ron, Flt3, and TrkA with IC50 values ranging from 3 nM to 80 nM. It demonstrates significant biological activity by inducing cell cycle arrest, promoting apoptotic cell death, and facilitating autophagy. KRC-108 showcases robust anti-tumor effects in vivo, particularly in HT29 colorectal cancer and NCI-H441 lung cancer xenograft models using athymic BALB/c nu/nu mice, making it a valuable reagent for cancer research applications.
Chemical Information
| Catalog Num | A31745 |
|---|---|
| M. Wt | 360.41 |
| Formula | C20H20N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1146944-35-5 |
| Synonyms | |
| SMILES | NC1=NC=C(C=C1C2=NC3=CC=CC=C3O2)C4=CN(N=C4)C5CCNCC5 |
Biological Activity
| Description | KRC-108 is a potent aminopyridine that functions as a multiple kinase inhibitor, targeting c-Met and its variants, Ron, Flt3, and TrkA with IC50 values ranging from 3 nM to 80 nM. It demonstrates significant biological activity by inducing cell cycle arrest, promoting apoptotic cell death, and facilitating autophagy. KRC-108 showcases robust anti-tumor effects in vivo, particularly in HT29 colorectal cancer and NCI-H441 lung cancer xenograft models using athymic BALB/c nu/nu mice, making it a valuable reagent for cancer research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
