Product Data Sheet
p,p'-DDD-d8
Catalog No. A31854
p,p'-DDD-d8 is a deuterium-labeled derivative of p,p'-DDD, an organochlorine insecticide and significant metabolite of p,p'-DDT. This compound acts as an agonist for estrogen receptors α (ERα) and β (ERβ), influencing cellular pathways linked to DNA damage, apoptosis, and necrosis in peripheral blood. Additionally, p,p'-DDD has been shown to promote cell proliferation in SKBR3 cells and activate the AP-1 transcription factor. Its effects on sleep patterns, particularly reducing sleep times induced by barbiturates and steroids in rat models, highlight its potential relevance in pharmacological studies.
Chemical Information
| Catalog Num | A31854 |
|---|---|
| M. Wt | 328.09 |
| Formula | C14H2D8Cl4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 93952-20-6 |
| Synonyms | 4,4'-DDD-d8; p,p'-Dichlorodiphenyl dichloroethane-d8 |
| SMILES | ClC(Cl)C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl |
Biological Activity
| Description | p,p'-DDD-d8 is a deuterium-labeled derivative of p,p'-DDD, an organochlorine insecticide and significant metabolite of p,p'-DDT. This compound acts as an agonist for estrogen receptors α (ERα) and β (ERβ), influencing cellular pathways linked to DNA damage, apoptosis, and necrosis in peripheral blood. Additionally, p,p'-DDD has been shown to promote cell proliferation in SKBR3 cells and activate the AP-1 transcription factor. Its effects on sleep patterns, particularly reducing sleep times induced by barbiturates and steroids in rat models, highlight its potential relevance in pharmacological studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
