Product Data Sheet
Tubulin-IN-51
Catalog No. A31860
Tubulin-IN-51 is a potent tubulin inhibitor with an IC50 of 31 nM, demonstrating oral bioavailability. It promotes tubulin polymerization in vitro and uniquely does not compete with Paclitaxel for binding sites, while inhibiting the interaction of Vinblastine with tubulin. This compound effectively downregulates the G1 phase of the cell cycle and induces apoptosis, leading to significant tumor growth inhibition in various nude mouse xenograft models. Tubulin-IN-51 is valuable for research in cancer biology and therapeutic applications targeting microtubule dynamics.
Chemical Information
| Catalog Num | A31860 |
|---|---|
| M. Wt | 464.82 |
| Formula | C18H18ClF5N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 849550-36-3 |
| Synonyms | |
| SMILES | FC1=CC(OCCCNC)=CC(F)=C1C2=C(N[C@@H](C(F)(F)F)C)N3N=CN=C3N=C2Cl |
Biological Activity
| Description | Tubulin-IN-51 is a potent tubulin inhibitor with an IC50 of 31 nM, demonstrating oral bioavailability. It promotes tubulin polymerization in vitro and uniquely does not compete with Paclitaxel for binding sites, while inhibiting the interaction of Vinblastine with tubulin. This compound effectively downregulates the G1 phase of the cell cycle and induces apoptosis, leading to significant tumor growth inhibition in various nude mouse xenograft models. Tubulin-IN-51 is valuable for research in cancer biology and therapeutic applications targeting microtubule dynamics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
