Product Data Sheet
Discodermolide
Catalog No. A31867
Discodermolide is a potent microtubule-stabilizing agent that exerts its effects by binding to tubulin and enhancing microtubule polymerization, leading to G2/M phase cell cycle arrest and apoptosis in cancer cells. With a Ki of 0.4 μM, it effectively inhibits cancer cell proliferation, including those resistant to Paclitaxel. Discodermolide is a valuable tool for research on breast and colon cancer, providing insights into microtubule dynamics and potential therapeutic strategies.
Chemical Information
| Catalog Num | A31867 |
|---|---|
| M. Wt | 593.79 |
| Formula | C33H55NO8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 127943-53-7 |
| Synonyms | NVP-XAA-296; XAA 296 |
| SMILES | C=C/C=C\[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C/C(C)=C\[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@@H](O)C[C@H](O1)[C@@H]([C@@H]([C@@H](C)C1=O)O)C |
Biological Activity
| Description | Discodermolide is a potent microtubule-stabilizing agent that exerts its effects by binding to tubulin and enhancing microtubule polymerization, leading to G2/M phase cell cycle arrest and apoptosis in cancer cells. With a Ki of 0.4 μM, it effectively inhibits cancer cell proliferation, including those resistant to Paclitaxel. Discodermolide is a valuable tool for research on breast and colon cancer, providing insights into microtubule dynamics and potential therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
