Product Data Sheet
Anti-CD20 Antibody (mAb 1.5.3)
Catalog No. A31874
Anti-CD20 Antibody (mAb 1.5.3) is a fully human IgG1 antibody targeting the CD20 antigen on B cells. This antibody exhibits significant pro-apoptotic activity in vitro and mediates both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). In various tumor xenograft models, mAb 1.5.3 demonstrates enhanced anti-tumor efficacy. Additionally, it achieves superior B-cell depletion in lymphoid tissues and bone marrow in primate pharmacodynamic studies, making it a valuable tool for research into B-cell malignancies.
Chemical Information
| Catalog Num | A31874 |
|---|---|
| M. Wt | |
| Formula | |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 922534-56-3 |
| Synonyms | |
| SMILES | N/A |
Biological Activity
| Description | Anti-CD20 Antibody (mAb 1.5.3) is a fully human IgG1 antibody targeting the CD20 antigen on B cells. This antibody exhibits significant pro-apoptotic activity in vitro and mediates both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). In various tumor xenograft models, mAb 1.5.3 demonstrates enhanced anti-tumor efficacy. Additionally, it achieves superior B-cell depletion in lymphoid tissues and bone marrow in primate pharmacodynamic studies, making it a valuable tool for research into B-cell malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
